Chemotherapy · 2009 · 27 citations · 0 references
PharmacyPharmacokineticsPharmacologyDrug ClearanceHepatic PharmacokineticsRenal PharmacokineticsDrug DispositionDrug Half-lifeHalf-life EstimationHepatic ClearanceMultiple-dose PharmacokineticsPharmacokinetics In Liver DiseaseDose-related Liver ToxicityDrug Elimination Half-lifeHepatic Half-lifePharmacokinetics In Liver DysfunctionRifampicin TherapyThreshold Dose ConceptThreshold Dose DeterminationThreshold Doses
Dose-related changes of the overall elimination rate constant were observed both after single and repeated administration of rifampicin. The threshold dose appears to be between 12 and 16 mg/kg in patients with normal liver function. Interference between rifampicin and bilirubin is confirmed. It does not appear dose-related and decreases during repeated administration.