Concepedia

Effect of Human Adipose Derived Stem Cells on Scar Formation and Remodeling in a Pig Model: A Pilot Study

In Sik Yun, Yeo Reum Jeon, Won Jai Lee, Jae Wook Lee, Dong Kyun Rah, Kwan Chul Tark, Dae Hyun Lew

Dermatologic Surgery · 2012 · 127 citations · 14 references

DOI

Abstract

Local injection of ASCs decreases scar size and provides better color quality and scar pliability. It decreases the activity of mast cells and inhibits the action of TGF-β against fibroblasts and positively stimulates scar remodeling through greater expression of MMP molecules.

References

14

Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies

Patricia A. Zuk, Min Zhu, Hiroshi Mizuno et al. · Tissue Engineering · 2001 · 7.9K citations

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Wound healing effect of adipose-derived stem cells: A critical role of secretory factors on human dermal fibroblasts

Won-Serk Kim, Byung-Soon Park, Jong-Hyuk Sung et al. · Journal of Dermatological Science · 2007 · 862 citations

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Fat Injection for Cases of Severe Burn Outcomes: A New Perspective of Scar Remodeling and Reduction

Marco Klinger, Mario Marazzi, D. Vigo et al. · Aesthetic Plastic Surgery · 2008 · 301 citations

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Evidence supporting antioxidant action of adipose-derived stem cells: Protection of human dermal fibroblasts from oxidative stress

Won-Serk Kim, Byung-Soon Park, Hyung-Ki Kim et al. · Journal of Dermatological Science · 2007 · 273 citations

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Human mesenchymal stem cells successfully improve skin-substitute wound healing

Hiroshi Nakagawa, Sadanori Akita, M. Fukui et al. · British Journal of Dermatology · 2005 · 232 citations