Pd‐ and Pt‐catalyzed H/D exchange methods and their application for internal MS standard preparation from a Sanofi‐Aventis perspective

Abstract

Abstract This review addresses method developments both homogeneous and heterogeneous Pd‐ and Pt‐catalyzed exchange, including catalyst activation principles and recent practical applications together with example procedures. Specific requirements for isotopically labelled internal MS standard preparation are discussed from a Sanofi‐Aventis perspective on recent examples. Copyright © 2010 John Wiley & Sons, Ltd.