Impaired growth, hematopoietic colony formation, and ribosome maturation in human cells depleted of Shwachman–Diamond syndrome protein SBDS

Abstract

We conclude that knockdown of SBDS leads to growth inhibition and defects in ribosome maturation, suggesting a role for wild-type SBDS in nuclear export of pre-60S subunits. Furthermore, knockdown of SBDS may interfere with eIF6 recycling.