Oligonucleotides containing a nucleotide analog with an ethynylfluorobenzene as nucleobase surrogate

A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines

Kenkichi Sonogashira, Yasuo Tohda, Nobue Hagihara · Tetrahedron Letters · 1975 · 5.1K citations

Natural Sciences, Chemistry, Catalysis +11

A thymidine triphosphate shape analog lacking Watson–Crick pairing ability is replicated with high sequence selectivity

Sean D. Moran, Rex X. Ren, Eric T. Kool · Proceedings of the National Academy of Sciences · 1997 · 310 citations

Life Sciences, Biochemistry, Molecular Biology +17

A Cytosine Analogue Capable of Clamp-Like Binding to a Guanine in Helical Nucleic Acids

Kuei‐Ying Lin, Mark D. Matteucci · Journal of the American Chemical Society · 1998 · 137 citations

Life Sciences, Biophysics, Molecular Biology +7

Potent and selective inhibition of gene expression by an antisense heptanucleotide

Richard W. Wagner, Mark D. Matteucci, Deborah Grant et al. · Nature Biotechnology · 1996 · 119 citations

Life Sciences, Molecular Biology, Molecular Genetics +15

Warum Pentose‐ und nicht Hexose‐Nucleinsäuren??. Teil V. (Purin‐Purin)‐Basenpaarung in der homo‐DNS‐Reihe: Guanin, Isoguanin, 2,6‐Diaminopurin und Xanthin

Katrin Groebke, Jürg Hunziker, W. Hamish Fraser et al. · Helvetica Chimica Acta · 1998 · 91 citations

Life Sciences, Biochemistry, Molecular Biology +17