Concepedia

Radical 5-exo cyclization of alkynoates with 2-oxoacetic acids for synthesis of 3-acylcoumarins

Tong Liu, Qiuping Ding, Qian‐Shou Zong, Guanyinsheng Qiu

Organic Chemistry Frontiers · 2015 · 97 citations · 37 references

DOI

Concepts

Abstract

A silver-promoted decarboxylative annulation of alkynoates with 2-oxoacetic acids leading to the formation of 3-acyl-4-arylcoumarins is reported. The process involves radical decarboxylative acylation, 5-<italic>exo</italic>cyclization, and ester migration.

References

37

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