Concepedia

Simultaneous Targeting of IL-1 and IL-18 Is Required for Protection against Inflammatory and Septic Shock

Tom Vanden Berghe, Dieter Demon, Pieter Bogaert, Benjamin Vandendriessche, Alain Goethals, Bart Depuydt, Marnik Vuylsteke, Ria Roelandt, Elien Van Wonterghem, Jill Vandenbroecke,

American Journal of Respiratory and Critical Care Medicine · 2014 · 172 citations · 43 references

DOIFull text

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Abstract

Our data point toward the therapeutic potential of neutralizing IL-1 and IL-18 simultaneously in sepsis, rather than inhibiting the upstream inflammatory caspases.

References

43

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

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Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

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Sanjeev Mariathasan, David S. Weiss, Kim Newton et al. · Nature · 2006 · 3K citations · Full text

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Daniel Rittirsch, Markus Huber‐Lang, Michael A. Flierl et al. · Nature Protocols · 2008 · 2.1K citations · Full text

, , +7