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Hepatoprotective Activity of Phenylethanoids from<i>Cistanche deserticola</i>
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1998
Year
Hepatoprotective ActivityLipid PeroxidationOrganic ChemistryToxicological MechanismOxidative StressRat Liver MicrosomesPhytopharmacologyToxicologyHepatotoxicityPhytochemicalOxysterolBiochemistryLiver PhysiologyPharmacologyDrug-induced Liver InjuryCultured RatNadph/ccl4-induced Lipid PeroxidationPhytochemistryMedicine
Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2'-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl4 or D-galactosamine (D-GalN). Acteoside (1) further showed pronounced anti-hepatotoxic activity against CCl4 in vivo.