Association between polymorphisms of folate-metabolizing enzymes and hematological malignancies

A Second Common Mutation in the Methylenetetrahydrofolate Reductase Gene: An Additional Risk Factor for Neural-Tube Defects?

N.M.J. van der Put, F. Gabreëls, E M Stevens et al. · The American Journal of Human Genetics · 1998 · 1.6K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy

Sheeja T. Pullarkat, Jan Stoehlmacher, Viviane S. Ghaderi et al. · The Pharmacogenomics Journal · 2001 · 573 citations

Medicine, Genetics, Oncology +13

Functional Analysis and DNA Polymorphism of the Tandemly Repeated Sequences in the 5'-terminal Regulatory Region of the Human Gene for Thymidylate Synthase.

Nobuyuki Horie, Hideo Aiba, Katsuhiko Oguro et al. · Cell Structure and Function · 1995 · 550 citations · Full text

Life Sciences, Genetics, Molecular Genetics +12

Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults

Christine F. Skibola, Martyn T. Smith, Eleanor Kane et al. · Proceedings of the National Academy of Sciences · 1999 · 530 citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer.

J. Chen, Edward L. Giovannucci, Karl T. Kelsey et al. · PubMed · 1996 · 520 citations

Life Sciences, Genetics, Molecular Genetics +17