Concepedia

Advanced Glycation End Products Are Direct Modulators of β-Cell Function

Melinda T. Coughlan, Felicia Y. T. Yap, David Tong, Sofianos Andrikopoulos, Anna Gasser, Vicki Thallas‐Bonke, Diane E. Webster, Jun‐ichi Miyazaki, Thomas W. H. Kay, Robyn M. Slattery,

Diabetes · 2011 · 151 citations · 49 references

DOIFull text

Open access

Abstract

These findings demonstrate that AGEs directly cause insulin secretory defects, most likely by impairing mitochondrial function, which may contribute to the development of T1D.

References

49

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

Kitt Falk Petersen, Sylvie Dufour, Douglas E. Befroy et al. · New England Journal of Medicine · 2004 · 2.2K citations · Full text

Establishment of a Pancreatic β Cell Line That Retains Glucose-Inducible Insulin Secretion: Special Reference to Expression of Glucose Transporter Isoforms*

Jun‐ichi Miyazaki, Kimi Araki, Eiji Yamato et al. · Endocrinology · 1990 · 1.3K citations

Structure Elucidation of a Senescence Cross-Link from Human Extracellular Matrix

David R. Sell, Vincent M. Monnier · Journal of Biological Chemistry · 1989 · 1.1K citations · Full text

Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

Andrew L. Carey, Gregory R. Steinberg, S. Lance Macaulay et al. · Diabetes · 2006 · 877 citations · Full text

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Accumulation of Maillard reaction products in skin collagen in diabetes and aging.

D G Dyer, John A. Dunn, S R Thorpe et al. · Journal of Clinical Investigation · 1993 · 766 citations · Full text

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