Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system

Autophagy in the Pathogenesis of Disease

Beth Levine, Guido Kroemer · Cell · 2008 · 7K citations · Full text

Life Sciences, Cell Biology, Pathobiology +10

Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Manuela Neumann, Deepak M. Sampathu, Linda K. Kwong et al. · Science · 2006 · 6.6K citations

Life Sciences, Neurology, Neuroscience +14

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Brinda Ravikumar, Zdenek Berger, J. Eric Davies et al. · Nature Genetics · 2004 · 2.3K citations

Life Sciences, Genetics, Neuroscience +17

Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and α-Synuclein

Sovan Sarkar, J. Eric Davies, Zebo Huang et al. · Journal of Biological Chemistry · 2006 · 1.1K citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs

S.-H.I. Ou, F Wu, David Harrich et al. · Journal of Virology · 1995 · 760 citations · Full text

Life Sciences, Genetics, Molecular Biology +17