Relative Toxicity of Selective Serotonin Reuptake Inhibitors (SSRIs) in Overdose

Abstract

This study shows SSRIs are relatively safe in overdose despite serotonin syndrome being common. The exception was citalopram, which was significantly associated with QTc prolongation. We believe that cardiac monitoring should be considered in citalopram overdose, particularly with large ingestions and patients with associated cardiac disease.