Polymer conjugates of doxorubicin bound through an amide and hydrazone bond: Impact of the carrier structure onto synergistic action in the treatment of solid tumours

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Pathology, Cancer Biology, Cancer Chemotherapy +17

Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee.

P. Vasey, Stan B. Kaye, Rachel Morrison et al. · PubMed · 1999 · 691 citations

Pathology, Pharmacotherapy, Maximum Tolerated Dose +16

New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties

Tomáš Etrych, M. Jelı́nková, Blanka Řı́hová et al. · Journal of Controlled Release · 2001 · 332 citations

Biofunctional Material, Medicinal Chemistry, Biochemistry +7

Polymeric drugs based on conjugates of synthetic and natural macromolecules

Karel Ulbrich, Vladimír Šubr, J. Strohalm et al. · Journal of Controlled Release · 2000 · 325 citations

Synthetic Macromolecule, Engineering, Macromolecular Engineering +11

Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer

Seymour · International Journal of Oncology · 2009 · 296 citations · Full text

Polymer-drug Conjugate, Medicine, Pharmacology +11