Improvement of tumor targeting and antitumor activity by a disulphide bond stabilized diabody expressed in Escherichia coli

"Diabodies": small bivalent and bispecific antibody fragments.

Philipp Holliger, Teresa Di Prospero, Greg Winter · Proceedings of the National Academy of Sciences · 1993 · 875 citations · Full text

Pharmacy, Biochemistry, Immunology +17

Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms.

Takashi Yokota, Diane E. Milenic, Marc Whitlow et al. · PubMed · 1992 · 826 citations

Pharmacy, Oncology, Pharmacokinetics +17

The Immunological Synapse of CTL Contains a Secretory Domain and Membrane Bridges

Jane C. Stinchcombe, Giovanna Bossi, Sarah Booth et al. · Immunity · 2001 · 801 citations · Full text

Life Sciences, Immunology, Molecular Biology +11

Isolation of a Highly Quiescent Subpopulation of Primitive Leukemic Cells in Chronic Myeloid Leukemia

Tessa L. Holyoake, Xiaoyan Jiang, Connie J. Eaves et al. · Blood · 1999 · 505 citations

Medicine, Cell Biology, Hematology +15

Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier.

Malik E. Juweid, Ronald D. Neumann, Chang H. Paik et al. · PubMed · 1992 · 405 citations

Pharmacy, Oncology, Pharmacology +17