BMJ · 1978 · 64 citations · 1 references
MedicineInfectious DiseasesPediatricsHemodialysisKidney TransplantationPediatric Infectious DiseasesBacterial InfectionsImmunosuppression In Kidney TransplantationNeonatal InfectionsNeonatal Infectious DiseasesPediatric Antibiotic TherapyPediatric Antimicrobial TherapyAntibiotic Dosing In DialysisAntimicrobial Therapy In InfantsDialysis-related InfectionsDuration Of Antibiotic TreatmentInfection After TransplantationInfections After TransplantationTransplantationTrough Concentrations
These findings emphasise the importance of daily close monitoring of peak and trough concentrations of aminoglycosides as well as concentrations before and after dialysis.A 24-hour Ion-call rapid assay service allowed us to make frequent changes in dosage and timing according to the results obtained.In our experience aminoglycosides are effective and safe in this group of patients, and treatment may thus be started before infection has been bacteriologically confirmed.Immunosuppression predisposes to candida infection after renal transplantation.We did not find more patients with the infection as a result of antibiotic treatment, and only two needed treatment with flucytosine.*More detailed information on each patient is available on request.
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