Concepedia

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

Daniel A. Muruve, Virginie Pétrilli, Anne K. Zaiss, Lindsay R. White, Sharon A. Clark, P. Joel Ross, Robin J. Parks, Jürg Tschopp

Nature · 2008 · 927 citations · 24 references

DOI

Concepts

References

24

Gout-associated uric acid crystals activate the NALP3 inflammasome

Fabio Martinon, Virginie Pétrilli, Annick Mayor et al. · Nature · 2006 · 5.2K citations

, , +11

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

Sanjeev Mariathasan, Kim Newton, Denise M. Monack et al. · Nature · 2004 · 1.8K citations

, , +14

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

Akinori Takaoka, Zhichao Wang, Myoung Kwon Choi et al. · Nature · 2007 · 1.7K citations

, , +14

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

Virginie Pétrilli, Stéphanie Papin, Catherine Dostert et al. · Cell Death and Differentiation · 2007 · 1.4K citations

, , +10

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

Teresa Fernandes‐Alnemri, Jiang Wu, Je‐Wook Yu et al. · Cell Death and Differentiation · 2007 · 1K citations · Full text

, , +15