Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

Sheng Zhou, John D. Schuetz, Kevin D. Bunting et al. · Nature Medicine · 2001 · 2.3K citations

Life Sciences, Cell Biology, Molecular Biology +7

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

Stephen G. Aller, Jodie Yu, Andrew B. Ward et al. · Science · 2009 · 1.9K citations · Full text

Medicine, Biochemistry, Pharmacology +12

A distinct “side population” of cells with high drug efflux capacity in human tumor cells

Charlotte Hirschmann-Jax, Angela E. Foster, Gerald Wulf et al. · Proceedings of the National Academy of Sciences · 2004 · 1.3K citations

Medicine, Cell Biology, Oncology +17

THE CALCULATION OF THE DOSAGE‐MORTALITY CURVE

C. I. Bliss · Annals of Applied Biology · 1935 · 1.1K citations

Pharmacy, Biostatistics, Toxicology +17

The Human ATP-Binding Cassette (ABC) Transporter Superfamily

Michael Dean · Genome Research · 2001 · 1.1K citations

Life Sciences, Genetics, Molecular Genetics +17