The Effect of Common Polymorphisms of the β₂-Adrenergic Receptor on Agonist-Mediated Vascular Desensitization

Abstract

The Arg16 polymorphism of the beta2-adrenergic receptor is associated with enhanced agonist-mediated desensitization in the vasculature, and the Glu27 polymorphism is associated with increased agonist-mediated responsiveness. Therefore, polymorphisms of the beta2-adrenergic receptor are potentially important determinants of the vascular response to stress.