NLRX1 is a regulator of mitochondrial antiviral immunity

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Mitsutoshi Yoneyama, Mika Kikuchi, Takashi Natsukawa et al. · Nature Immunology · 2004 · 3.8K citations

Essential Function, Viral Replication, Molecular Virology +10

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

Rashu B. Seth, Lijun Sun, Chee-Kwee Ea et al. · Cell · 2005 · 3.2K citations · Full text

Signal Transduction, Mitochondrial Function, Mitochondrial Dynamic +6

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Taro Kawai, Ken Takahashi, Shintaro Sato et al. · Nature Immunology · 2005 · 2.5K citations

Mda5-mediated Type, Signal Transduction, Natural Sciences +6

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

Etienne Meylan, Joseph Curran, Kay Hofmann et al. · Nature · 2005 · 2.4K citations · Full text

Adaptor Protein, Rig-i Antiviral Pathway, Hepatitis C Virus +8

PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization

Kenta Nakai · Trends in Biochemical Sciences · 1999 · 2.2K citations

Functional Genomics, Interactomics, Medicine +13