Discovery of 6-Oxo-3-(2-phenylpyrazolo[1,5-<i>a</i>]pyridin-3-yl)-1(6<i>H</i>)-pyridazinebutanoic Acid (FK 838): A Novel Non-Xanthine Adenosine A₁Receptor Antagonist with Potent Diuretic Activity

Abstract

ADVERTISEMENT RETURN TO ISSUELetterNEXTDiscovery of 6-Oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinebutanoic Acid (FK 838): A Novel Non-Xanthine Adenosine A1 Receptor Antagonist with Potent Diuretic ActivityAtsushi Akahane, Hirohito Katayama, Takafumi Mitsunaga, Takeshi Kato, Takayoshi Kinoshita, Yasuhiro Kita, Takahiro Kusunoki, Takao Terai, Keizo Yoshida, and Youichi ShiokawaView Author Information Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Company, Ltd., 1-6, 2-chome, Kashima, Yodogawa-ku, Osaka 532-8514, Japan Cite this: J. Med. Chem. 1999, 42, 5, 779–783Publication Date (Web):February 20, 1999Publication History Received30 November 1998Published online20 February 1999Published inissue 1 March 1999https://pubs.acs.org/doi/10.1021/jm980671whttps://doi.org/10.1021/jm980671wrapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views669Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Antagonists,Nucleic acids,Receptors,Rodent models,Solubility Get e-Alerts