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Ethacrynic Acid Exhibits Selective Toxicity to Chronic Lymphocytic Leukemia Cells by Inhibition of the Wnt/β-Catenin Pathway

DOIFull Paper Access

93

Citations

36

References

2009

Year

Desheng Lu, Jerry X. Liu, Tomoyuki Endo, Haowen Zhou, Shiyin Yao, Karl Willert, Ingo G.H. Schmidt‐Wolf, Thomas J. Kipps, Dennis A. Carson
PLoS ONE

Abstract

Our studies indicate that EA selectively suppresses CLL survival due to inhibition of Wnt/beta-catenin signaling. Antagonizing Wnt signaling in CLL with EA or related drugs may represent an effective treatment of this disease.

References

YearCitations

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