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Activin-Like Kinase 5 (ALK5) Mediates Abnormal Proliferation of Vascular Smooth Muscle Cells from Patients with Familial Pulmonary Arterial Hypertension and Is Involved in the Progression of Experimental Pulmonary Arterial Hypertension Induced by Monocrotaline

Matthew Thomas, Cerys Docx, Alan Holmes, Sarah Beach, Nicholas Duggan, Karen England, Catherine Leblanc, Clemence Lebret, Francis Schindler, Farheen Raza,

American Journal Of Pathology · 2008 · 108 citations · 23 references

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23

Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension

Kirk B. Lane, Rajiv D. Machado, Michael W. Pauciulo et al. · Nature Genetics · 2000 · 1.5K citations

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Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-β family

Jennifer R. Thomson · Journal of Medical Genetics · 2000 · 734 citations · Full text

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Altered Growth Responses of Pulmonary Artery Smooth Muscle Cells From Patients With Primary Pulmonary Hypertension to Transforming Growth Factor-β <sub>1</sub> and Bone Morphogenetic Proteins

Nicholas W. Morrell, Xudong Yang, Paul D. Upton et al. · Circulation · 2001 · 457 citations · Full text

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Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells

Shen Zhang, Ivana Fantozzi, Donna D. Tigno et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2003 · 255 citations

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Activation of Soluble Guanylate Cyclase Reverses Experimental Pulmonary Hypertension and Vascular Remodeling

Rio Dumitrascu, Hossein Ardeschir Ghofrani, Eva Dony et al. · Circulation · 2006 · 222 citations

, , +14