Downregulation of Parkin Damages Antioxidant Defenses and Enhances Proteasome Inhibition-Induced Toxicity in PC12 Cells

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Andrew Fire, Siqun Xu, Mary K. Montgomery et al. · Nature · 1998 · 15.3K citations · Full text

Life Sciences, Genetics, Molecular Biology +8

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Tohru Kitada, Shuichi Asakawa, Nobutaka Hattori et al. · Nature · 1998 · 5.2K citations

Life Sciences, Genetics, Molecular Genetics +10

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Hideki Shimura, Nobutaka Hattori, Shinichiro Kubo et al. · Nature Genetics · 2000 · 2K citations

Life Sciences, Molecular Biology, Neuroscience +14

Association between Early-Onset Parkinson's Disease and Mutations in the<i>Parkin</i>Gene

Christoph B. Lücking, Alexandra Dürr, Vincenzo Bonifati et al. · New England Journal of Medicine · 2000 · 1.4K citations · Full text

Life Sciences, Genetics, Neurology +14

Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice

James Palacino, Dijana Šagi, Matthew S. Goldberg et al. · Journal of Biological Chemistry · 2004 · 998 citations · Full text

Life Sciences, Biochemistry, Cell Biology +16