Concepedia

Design, synthesis, and structure–activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors

Yorinobu Yasuda, Takeaki Arakawa, Yumi Nawata, Sayaka Shimada, Shinya Oishi, Nobutaka Fujii, Shinichi Nishimura, Akira Hattori, Hideaki Kakeya

Bioorganic & Medicinal Chemistry · 2015 · 29 citations · 8 references

DOIFull text

Open access

Concepts

References

8

Lipophilicity in drug discovery

Michael J. Waring · Expert Opinion on Drug Discovery · 2010 · 844 citations

, , +13

The Design of Leadlike Combinatorial Libraries

Simon J. Teague, A. M. Davis, Paul D. Leeson et al. · Angewandte Chemie International Edition · 1999 · 810 citations

, , +17

4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells

John Wai, Melissa S. Egbertson, Linda S. Payne et al. · Journal of Medicinal Chemistry · 2000 · 187 citations · Full text

, , +11

Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels

Hiroshi Harada, Masahiro Inoue, Satoshi Itasaka et al. · Nature Communications · 2012 · 177 citations · Full text

, , +16

A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1α

Shan Hua Li, Dong Hoon Shin, Yang‐Sook Chun et al. · Molecular Cancer Therapeutics · 2008 · 154 citations · Full text

, , +15