Ultraviolet Exposure as the Main Initiator of p53 Mutations in Basal Cell Carcinomas from Psoralen and Ultraviolet A-Treated Patients with Psoriasis

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

Marc S. Greenblatt, W P Bennett, Monica Hollstein et al. · PubMed · 1994 · 3.5K citations

Tumor Biology, Cancer Pathology, Molecular Pathogenesis +9

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

Yunje Cho, Svetlana S. Gorina, Philip D. Jeffrey et al. · Science · 1994 · 2.5K citations

Chromatin, Crystal Structure, Dna Binding +15

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

Shinya Shibutani, Masaru Takeshita, Arthur P. Grollman · Nature · 1991 · 2.2K citations

Biosynthesis, Bioorganic Chemistry, Biochemistry +10

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

Douglas E. Brash, Jeffrey A. Rudolph, J A Simon et al. · Proceedings of the National Academy of Sciences · 1991 · 1.9K citations · Full text

Tumor Biology, Squamous Cell Carcinoma, Dipyrimidine Specificity +14

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

Keith C. Cheng, D S Cahill, Hiroshi Kasai et al. · Journal of Biological Chemistry · 1992 · 1.8K citations · Full text