Orthogonal Protecting Groups in the Synthesis of Tryptophanyl‐Hexahydropyrroloindoles

Abstract

Abstract The synthesis of various polycyclic systems containing aC 3a –N i bond between a hexahydropyrrolo[2,3‐ b ]indole and an indole tryptophan is described here. A series of experiments were performed to determine the best combination of five orthogonal protecting groups and the best reaction conditions for formation of said bond, which is a common feature among many recently discovered marine natural products.