Concepedia

Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity

Lisa K. Brents, Anna Gallus‐Zawada, Anna Radomińska‐Pandya, Tamara Vasiljevik, Thomas E. Prisinzano, William E. Fantegrossi, Jeffery H. Moran, Paul L. Prather

Biochemical Pharmacology · 2012 · 142 citations · 46 references

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References

46

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

, , +14

Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers

Jussi Hirvonen, Robert S. Goodwin, Cheng‐Ta Li et al. · Molecular Psychiatry · 2011 · 584 citations

, , +13

Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity

Joseph Tam, Kiran Vemuri, Jie Liu et al. · Journal of Clinical Investigation · 2010 · 451 citations · Full text

, , +16

The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.

P.Blaise Smith, David M. Compton, Sandra P. Welch et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 394 citations

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Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds

Sebastian Dresen, Nerea Ferreirós, Michael Pütz et al. · Journal of Mass Spectrometry · 2010 · 308 citations

, , +8