mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

P. Early, Huarong Huang, Mark M. Davis et al. · Cell · 1980 · 868 citations

Life Sciences, Genetics, Molecular Genetics +6

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

Hitoshi Sakano, Richard A. Maki, Yoshikazu Kurosawa et al. · Nature · 1980 · 797 citations

Life Sciences, Immunology, Molecular Biology +11

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

F W Alt, D Baltimore · Proceedings of the National Academy of Sciences · 1982 · 760 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

Alfred L.M. Bothwell, Michael Paskind, Michael Reth et al. · Cell · 1981 · 678 citations

Life Sciences, Genetics, Immunology +17

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

Patricia J. Gearhart, Nelson D. Johnson, R. Douglas et al. · Nature · 1981 · 503 citations

Life Sciences, Biochemistry, Immunology +12