Concepedia

Synthesis of novel substituted pyridines as inhibitors of endothelin coverting enzyme-1 (ECE-1)

Mark A. Massa, William C. Patt, Kyunghye Ahn, Andre M. Sisneros, Sarah B. Herman, Annette M. Doherty

Bioorganic & Medicinal Chemistry Letters · 1998 · 17 citations · 13 references

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A novel potent vasoconstrictor peptide produced by vascular endothelial cells

Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura et al. · Nature · 1988 · 10.8K citations · Full text

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ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

Dong Xu, Noriaki Emoto, Adel Giaid et al. · Cell · 1994 · 930 citations

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Synthesis of various 5‐substituted uracils

Dan Peters, Anna‐Britta Hörnfeldt, Salo Gronowitz · Journal of Heterocyclic Chemistry · 1990 · 122 citations

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Discovery of a Novel Series of Orally Active Non-Peptide Endothelin-A (ETA) Receptor-Selective Antagonists

Annette M. Doherty, William C. Patt, Jeremy J. Edmunds et al. · Journal of Medicinal Chemistry · 1995 · 109 citations · Full text

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Total Synthesis of Dimethyl Sulfomycinamate

T. Ross Kelly, Fengrui Lang · The Journal of Organic Chemistry · 1996 · 96 citations

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