Synthesis of the oxazole- and diene-containing C9–C23 fragment of the type a streptogramin antibiotics

Abstract

The right-hand portion (3) of the type A streptogramin antibiotics was synthesized in non-racemic form through use of a Horner-Wadsworth-Emmons reaction for diene construction, an asymmetric aldol condensation, and a zinc-promoted oxazole addition reaction.