Induction of β(A4)-amyloid in primates by injection of Alzheimer’s disease brain homogenate

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Alison Goate, Marie‐Christine Chartier‐Harlin, Jeremy Brown et al. · Nature · 1991 · 4.6K citations

Life Sciences, Genetics, Molecular Genetics +16

Amyloid β-peptide is produced by cultured cells during normal metabolism

Christian Haass, Michael G. Schlossmacher, Albert Y. Hung et al. · Nature · 1992 · 1.9K citations

Life Sciences, Biochemistry, Cell Biology +15

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

Peter Seubert, Carmen Vigo‐Pelfrey, Fred Esch et al. · Nature · 1992 · 1.7K citations

Life Sciences, Biochemistry, Neuroscience +13

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

Efrat Levy, M. D. Carman, Ivan Fernandez‐Madrid et al. · Science · 1990 · 1.4K citations

Life Sciences, Genetics, Molecular Genetics +17

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

Marie‐Christine Chartier‐Harlin, Fiona Crawford, Henry Houlden et al. · Nature · 1991 · 1.2K citations

Life Sciences, Genetics, Molecular Genetics +16