Concepedia

Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins

Raphael M. Franzini, Angela Nauer, Jörg Scheuermann, Dario Neri

Chemical Communications · 2015 · 37 citations · 24 references

DOI

Concepts

Abstract

Parallel affinity screening of a DNA-encoded chemical library against rat, bovine and human serum albumin allowed the identification of small-molecule ligands with distinctive binding specificities to the individual proteins.

References

24

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DNA-Encoded Chemical Libraries: Advancing beyond Conventional Small-Molecule Libraries

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High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

Luca Mannocci, Yixin Zhang, Jörg Scheuermann et al. · Proceedings of the National Academy of Sciences · 2008 · 232 citations · Full text

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