Concepedia

Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors

Xiaohua Huang, Cliff C. Cheng, Thierry Fischmann, José S. Duca, Matthew Richards, Praveen K. Tadikonda, Panduranga Adulla Reddy, Lianyun Zhao, M. Arshad Siddiqui, David Parry,

Bioorganic & Medicinal Chemistry Letters · 2013 · 35 citations · 16 references

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16

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

Emmy P. Rogakou, Duane R. Pilch, Ann H. Orr et al. · Journal of Biological Chemistry · 1998 · 5.3K citations · Full text

Rapid Destruction of Human Cdc25A in Response to DNA Damage

Niels Mailand, Jacob Falck, Claudia Lukas et al. · Science · 2000 · 767 citations

Chk1 Mediates S and G2 Arrests through Cdc25A Degradation in Response to DNA-damaging Agents

Zhan Xiao, Zehan Chen, Angelo Gunasekera et al. · Journal of Biological Chemistry · 2003 · 378 citations · Full text

Monodentate Phosphines Provide Highly Active Catalysts for Pd‐Catalyzed CN Bond‐Forming Reactions of Heteroaromatic Halides/Amines and (H)N‐Heterocycles

Kevin W. Anderson, Rachel E. Tundel, Takashi Ikawa et al. · Angewandte Chemie International Edition · 2006 · 291 citations

Cdk2 Kinase Is Required for Entry into Mitosis as a Positive Regulator of Cdc2–Cyclin B Kinase Activity

Thomas M. Guadagno, John W. Newport · Cell · 1996 · 218 citations · Full text

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