Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

Zilong Wen, Zhong Zhong, James Darnell · Cell · 1995 · 2K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

Long Pang, Takeshi Sawada, Stuart J. Decker et al. · Journal of Biological Chemistry · 1995 · 905 citations · Full text

Life Sciences, Neurobiology, Neuroscience +15

Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice

Merav Socolovsky, Amy E.J. Fallon, Stream Wang et al. · Cell · 1999 · 698 citations · Full text

Life Sciences, Developmental Biology, Genetics +13

A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

William Matthews, Craig T. Jordan, Gordon Wiegand et al. · Cell · 1991 · 600 citations

Life Sciences, Cell Biology, Hematology +16

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

Katrin Mackarehtschian, Jeff Hardin, Katrd A. Moore et al. · Immunity · 1995 · 578 citations · Full text

Life Sciences, Developmental Biology, Genetics +16