Annals of Plastic Surgery · 1994 · 10 citations · 0 references
DentistryBiomedical EngineeringSurgeryBiocompatibilityInflammationTissue EngineeringBioceramicsCollagen-based BiomaterialsConnective Tissue BreakdownGastrointestinal InflammationSoft Tissue GraftingWound InflammationAcute Inflammatory ResponseCollagen DressingsCollagen-based Soft Tissue Regeneration MaterialsInflammatory Response To Graft MaterialSoft Tissue Graft MaterialsSoft Tissue Healing Around ImplantsSubcutaneous Implantation Testing
The fate of the Zyderm II, Zyplast, Vicryl, and chromic gut was histologically examined up to 1 year following subcutaneous implantation into rats. Our data demonstrated both Zyderm II and Zyplast to be inert materials without inflammatory response; there was no difference in long-term persistence between these two collagens. Both Vicryl and chromic gut implants caused an intense inflammatory response at 1 month, and Vicryl was completely resorbed before 6 months. The degree of inflammation associated with chromic gut diminished over time, and approximately 67% of the material persisted without reaction up to 1 year.