Simple and One-Pot Protocol for Synthesis of Indene-spiro-oxindoles Involving Tandem Prins and Friedel−Crafts Reactions

Abstract

[reaction: see text] A simple and one-pot protocol for the synthesis of indene-spiro-oxindole derivatives via TiCl4-mediated reaction between 1,1-diarylethylenes and isatin derivatives involving construction of two carbon-carbon bonds through tandem Prins and intramolecular Friedel-Crafts (PFC) reactions has been described. A plausible mechanism for this transformation is also presented.