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2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2

Danielle K. Neff, Alice Lee-Dutra, Jonathan M. Blevitt, Frank U. Axe, Michael D. Hack, Johnathan Buma, Raymond Rynberg, Anders Brunmark, Lars Karlsson, J. Guy Breitenbucher

Bioorganic & Medicinal Chemistry Letters · 2007 · 33 citations · 6 references

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6

The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Jacob Falck, Niels Mailand, Randi G. Syljuåsen et al. · Nature · 2001 · 1.1K citations

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Chk2‐deficient mice exhibit radioresistance and defective p53‐mediated transcription

Hiroyuki Takai, Kazuhito Naka, Yuki Okada et al. · The EMBO Journal · 2002 · 435 citations · Full text

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Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner

Atsushi Hirao, Alison Cheung, Gordon S. Duncan et al. · Molecular and Cellular Biology · 2002 · 411 citations · Full text

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Checkpoint Kinase Inhibitors:  SAR and Radioprotective Properties of a Series of 2-Arylbenzimidazoles

Kristen L. Arienti, Anders Brunmark, Frank U. Axe et al. · Journal of Medicinal Chemistry · 2004 · 175 citations · Full text

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Identification of novel, selective and potent Chk2 inhibitors

Gary Larson, Shunqi Yan, Huanming Chen et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 40 citations · Full text

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