PubMed · 1993 · 16 citations · 12 references
Life SciencesBiochemistryNeuroscienceMolecular NeurobiologyMolecular NeuroscienceNeurochemistryDisulfide Bond FormationNeurotrophic FactorsChinese Hamster Ovary Cell ExpressionChinese Hamster Ovary CellsDisulfide Bond StructureDisulfide ContributionsDisulfide LinkersNeurotrophic Factor SignalingPeptide Mass SpectrometryPeptide Structure Analysis
Three disulfide linkages of recombinant human brain-derived neurotrophic factor (BDNF) were determined by peptide sequence analysis and characterized by mass spectrometry. The three disulfide bonds for BDNF expressed in Chinese hamster ovary cells include Cys-13-Cys-80, Cys-58-Cys-109 and Cys-68-Cys-111, and the disulfide structure was homologous to that of nerve growth factor.
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Purification of a new neurotrophic factor from mammalian brain.
Yves‐Alain Barde, David Edgar, H. Thoenen · The EMBO Journal · 1982 · 1.8K citations · Full text
Molecular cloning and expression of brain-derived neurotrophic factor
Joachim Leibrock, Friedrich Lottspeich, Andreas Höhn et al. · Nature · 1989 · 1.5K citations
Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF
Peter C. Maisonpierre, Leonardo Belluscio, Stephen P. Squinto et al. · Science · 1990 · 1.3K citations