Development and validation of a rapid HPLC method for simultaneous determination of tramadol, and its two main metabolites in human plasma

The hypoalgesic effect of tramadol in relation to CYP2D6*

Lars K. Poulsen, Lars Arendt‐Nielsen, Kim Brøsen et al. · Clinical Pharmacology & Therapeutics · 1996 · 387 citations

Nursing, Pharmacology, Pharmacotherapy +17

Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes.

Vangala V. Subrahmanyam, A. B. Renwick, D. Gareth Walters et al. · PubMed · 2001 · 190 citations

Medicine, Biochemistry, Pharmacology +17

[Biotransformation of tramadol in man and animal (author's transl)].

W Lintz, S Erlaçin, E Frankus et al. · PubMed · 1981 · 143 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Method development and validation of a high-performance liquid chromatographic method for tramadol in human plasma using liquid–liquid extraction

Siew Hua Gan, Rusli Ismail, W. A. Wan Adnan et al. · Journal of Chromatography B · 2002 · 88 citations

Pharmacy, Pharmaceutical Analysis, Pharmacology +15

Validation of a high-performance liquid chromatography method for tramadol and o-desmethyltramadol in human plasma using solid-phase extraction

Siew Hua Gan, Rusli Ismail · Journal of Chromatography B Biomedical Sciences and Applications · 2001 · 84 citations

Pharmacy, Pharmaceutical Analysis, Pharmacology +15