Up-regulation of PI3K/Akt signaling by 17β-estradiol through activation of estrogen receptor-α, but not estrogen receptor-β, and stimulates cell growth in breast cancer cells

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Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

Vuk Stambolic, Akira Suzuki, José Luís de la Pompa et al. · Cell · 1998 · 2.6K citations · Full text

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Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

Tommaso Simoncini, Ali Hafezi‐Moghadam, Derek P. Brazil et al. · Nature · 2000 · 1.4K citations · Full text

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The lipid phosphatase activity of PTEN is critical for its tumor supressor function

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Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

Malcolm Whitman, C. Peter Downes, Marilyn L. Keeler et al. · Nature · 1988 · 1K citations

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