THE NATURE OF THE RENAL LESION WITH SULFAPYRIDINE THERAPY

Abstract

Although the gross presence of urinary calculi as a consequence of sulfapyridine therapy has been reported both experimentally and clinically,¹no calculi have been seen in microscopic preparations. The most constant finding in the microscopic examination of the kidneys in the reported postmortem examinations has been marked dilatation of both convoluted and collecting tubules and of the glomerular spaces. The cause and nature of these lesions have not been demonstrated, however. The calculi and the associated disturbances in renal function constitute the most disturbing complication of the use of sulfapyridine and, as stressed by Bensley,²measures designed to prevent such a complication cannot be adequately determined until more is known of its cause. In the case reported here calculi, present grossly, were likewise demonstrable in the histologic preparations of the kidneys, and the etiology of the described cortical lesions could be determined. <h3>REPORT OF CASE</h3> A child aged