OBSERVATIONS UPON THE EXPERIMENTAL AND CLINICAL USE OF SULFAPYRIDINE. II. THE TREATMENT OF PNEUMOCOCCAL PNEUMONIA WITH SULFAPYRIDINE

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Article1 September 1939OBSERVATIONS UPON THE EXPERIMENTAL AND CLINICAL USE OF SULFAPYRIDINE. II. THE TREATMENT OF PNEUMOCOCCAL PNEUMONIA WITH SULFAPYRIDINEPERRIN H. LONG, M.D., W. BARRY WOOD JR., M.D.PERRIN H. LONG, M.D.Search for more papers by this author, W. BARRY WOOD JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-3-487 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe rational utilization of any promising compound in the field of clinical chemotherapy is dependent upon a knowledge of its absorption by, distribution in, and excretion from the body. Early in the course of our studies upon sulfapyridine, we1noted that the drug was not readily soluble, and in comparison with sulfanilamide, poorly absorbed, when it was administered to animals by the oral route. While increasing doses gave blood levels of increasing amounts, these concentrations were not at all proportional to the dose, and certain individual animals showed marked variations from time to time in their ability to absorb the...Bibliography1. LONGFEINSTONE PHWH: Observations upon the absorption and excretion of sulfapyridine, Proc. Soc. Exper. Biol. and Med., 1938, xxxix, 486. CrossrefGoogle Scholar2. MARSHALLBRATTONLITCHFIELD EKACJT: The toxicity and absorption of 2-sulfanilamidopyridine and its soluble salt, Science, 1938, lxxxviii, 597. CrossrefGoogle Scholar3. BAINESWIEN EJR: The absorption and excretion of 2-sulphanilylaminopyridine, Quart. Jr. Pharm. and Pharmacol., 1939, xii, 4. Google Scholar4. BRATTONMARSHALL ACEK: A new coupling compound for sulfanilamide determination, Jr. Biol. Chem., 1939, cxxviii, 537. CrossrefGoogle Scholar5. ANTOPOLROBINSON WH: Urolithiasis and renal pathology after oral administration of 2 (sulfanilylamino)-pyridine (sulfapyridine), Proc. Soc. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Nature and Treatment of Pneumococcal PneumoniaDie PneumonienRENAL COMPLICATIONS OF SULPHAPYRIDINE THERAPYIntensive Treatment of Gonorrh a and Non-Specific Urethritis with SulphapyridineThe Treatment of Pulmonary Infections with Sulfanilamide, Sulfapyridine, and SulfathiazoleAcute hemolytic anemia developing during therapy with substances belonging to the sulphanilamide groupLiteraturverzeichnisThe Occurrence of Urologic Complications in Humans Following Sulfapyridine Therapy 1 September 1939Volume 13, Issue 3Page: 487-512KeywordsAttentionBloodChemotherapyDrugsExcretionHospital medicinePatientsPneumoniaSodium ePublished: 1 December 2008 Issue Published: 1 September 1939 PDF downloadLoading ...