Neuropathological evidence for ischemia in the white matter of the dorsolateral prefrontal cortex in late‐life depression

Abstract

These findings are consistent with white matter ischemia in the DLPFC and lend support to the 'vascular depression' hypothesis. They implicate the DLPFC as an important site in the pathogenesis of late-life depression and have major implications for the understanding and management of late-life depression and raise the possibility of novel treatments being introduced in the future.