Protective effect of celastrol in rat cerebral ischemia model: Down-regulating p-JNK, p-c-Jun and NF-κB

Reversible middle cerebral artery occlusion without craniectomy in rats.

Enrique Zea Longa, Philip R. Weinstein, Shaun W. Carlson et al. · Stroke · 1989 · 7.5K citations · Full text

Medicine, Neuroscience, Surgery +17

A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

Tiziana Borsello, Lorenz Hirt, Alessandro Vercelli et al. · Nature Medicine · 2003 · 657 citations

Life Sciences, Neuroscience, Pharmacology +16

Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke.

E. Sander Connolly, Christopher J. Winfree, Timothy A. Springer et al. · Journal of Clinical Investigation · 1996 · 528 citations · Full text

Life Sciences, Immunology, Neurology +17

Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia

Chenhui Yang, Xiangjian Zhang, Hongguang Fan et al. · Brain Research · 2009 · 439 citations

Life Sciences, Neurobiology, Neuroscience +15

Constitutive NF-kB Activity in Neurons

Christian Kaltschmidt, Barbara Kaltschmidt, Harald Neumann et al. · Molecular and Cellular Biology · 1994 · 396 citations

Life Sciences, Molecular Biology, Neuroscience +12