A Modified Human Tissue Plasminogen Activator with Extended Half–Life In Vivo

The thrombolysis in myocardial infarction (TIMI) trial. Phase I findings

Hiltrud S. Mueller, A. R. DYER, Mark A. Greenberg · 1985 · 3.6K citations

Percutaneous Coronary Intervention, Thrombosis, Cardiovascular Disease +7

The Thrombolysis in Myocardial Infarction (TIMI) Trial

New England Journal of Medicine · 1985 · 3.2K citations

Thrombosis, Cardiovascular Disease, Thrombolytic Therapy +10

Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli

Diane Pennica, William E. Holmes, William J. Kohr et al. · Nature · 1983 · 1.2K citations

E. Coli, Protein Expression, Natural Sciences +11

On the Regulation and Control of Fibrinolysis

D Collen · Thrombosis and Haemostasis · 1980 · 1.1K citations

Protein Function, Protein Expression, Biochemistry +9

Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture.

D.C. Rijken, Désiré Collen · Journal of Biological Chemistry · 1981 · 788 citations · Full text

Protein Secretion, Cell Culture, Cytoskeleton +23