Concepedia

Limited interaction between tacrolimus and P-glycoprotein in the rat small intestine

Hiroshi Saitoh, Yuko Saikachi, Mikako Kobayashi, Michiko Yamaguchi, Masako Oda, Yoshimitsu Yuhki, Kazuhito Achiwa, Koji Tadano, Yasushi Takahashi, Bruce J. Aungst

European Journal of Pharmaceutical Sciences · 2006 · 39 citations · 39 references

DOI

Concepts

References

39

Characterization of Interintestinal and Intraintestinal Variations in Human CYP3A-Dependent Metabolism

Mary F. Paine, Mehraneh Khalighi, Jeannine M. Fisher et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 792 citations

, , +17

Human P-glycoprotein transports cyclosporin A and FK506.

Takashi Saeki, Kazumitsu Ueda, Yusuke Tanigawara et al. · Journal of Biological Chemistry · 1993 · 685 citations · Full text

, , +15

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

Kazumitsu Ueda, Noboru Okamura, Midori Hirai et al. · Journal of Biological Chemistry · 1992 · 676 citations · Full text

, , +15

Interrelationship Between Substrates and Inhibitors of Human CYP3A and P-Glycoprotein

Richard B. Kirn, Christoph Wandel, Brenda F. Leake et al. · Pharmaceutical Research · 1999 · 460 citations

, , +10

Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat.

Martin Sattler, F. Peter Guengerich, Chul‐Ho Yun et al. · Drug Metabolism and Disposition · 1992 · 389 citations

, , +17