P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes 1 1Abbreviations: FTI, farnesyl-protein transferase inhibitor; FTase, farnesyl-protein transferase; and LC-MS, liquid chromatography-mass spectrometry.

Publication | Closed Access

DOI

Citations

References

2001

Year

Masato Chiba, Cuyue Tang, William Neway, Theresa M. Williams, S. J. DESOLMS, Christopher J Dinsmore, John Wai, Jiunn H. Lin

Biochemical Pharmacology

BiochemistryP450 InteractionLiver PhysiologyLiquid Chromatography-mass SpectrometryMedicineMetabolomic ProfilingHepatotoxicityMetabolic ProfilingMetabolismPharmacologyFarnesyl-protein TransferaseDrug Discovery