Concepedia

Practical Syntheses of Oxindole Derivatives: Chemical Development towards 2-(5-Chloro-2-oxo-2,3-dihydroindol-1-yl)acetamide and (<i>S</i>)-2-(5-Chloro-2-oxo-2,3-dihydroindol-1-yl)propionamide

Fabienne Broeders, Laurent Defrère, Marie-France Deltent, Frank Driessens, Frédéric Gilson, Luc Grooters, Xavier Ikonomakos, Frédéric Limauge, Emmanuel Sergeef, Natacha Verstraeten

Organic Process Research & Development · 2009 · 11 citations · 43 references

DOI

Concepts

Abstract

We describe development of scalable syntheses of novel oxindole-type SV2A ligands with improved potency towards seizure suppression.

References

43

Early Identification of Refractory Epilepsy

Patrick Kwan, Martin J. Brodie · New England Journal of Medicine · 2000 · 5.2K citations · Full text

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Modern Synthetic Methods for Copper‐Mediated C(aryl)O, C(aryl)N, and C(aryl)S Bond Formation

Steven V. Ley · Angewandte Chemie International Edition · 2003 · 2.5K citations

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Modern Synthetic Methods for Copper‐Mediated C(aryl)O, C(aryl)N, and C(aryl)S Bond Formation

Steven V. Ley, Andrew W. Thomas · Angewandte Chemie International Edition · 2004 · 2.1K citations · Full text

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The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam

Berkley A. Lynch, Nathalie Lambeng, Karl Nocka et al. · Proceedings of the National Academy of Sciences · 2004 · 1.6K citations · Full text

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Palladium-Catalyzed α-Arylation of Carbonyl Compounds and Nitriles

Darcy A. Culkin, John F. Hartwig · Accounts of Chemical Research · 2003 · 934 citations

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