Concepedia

The Tumor Suppressor DAP Kinase Is a Target of RSK-Mediated Survival Signaling

Rana Anjum, Philippe P. Roux, Bryan A. Ballif, Steven P. Gygi, John Blenis

Current Biology · 2005 · 161 citations · 19 references

Open access

Concepts

Life SciencesCancer BiologyOncologyCell SignalingMolecular OncologySignal TransductionApoptotic SignalingCancer Cell SignalingCancer ProgressionOncogenic Signaling PathwaysProtein Kinase CascadesTumor Suppressor GenesCancer Cell Survival SignalingCancer Signaling PathwaysExtracellular Signal-regulated Kinase SignalingTumor Cell Survival PathwaysTumor Suppressor Pathways

References

19

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

Brendan D. Manning, Andrew R. Tee, M. Nicole Logsdon et al. · Molecular Cell · 2002 · 1.6K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +12

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

Philippe P. Roux, Bryan A. Ballif, Rana Anjum et al. · Proceedings of the National Academy of Sciences · 2004 · 741 citations · Full text

Life Sciences, Cell Biology, Oncology +17

Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals.

Bryan A. Ballif, John Blenis · PubMed · 2001 · 425 citations

Life Sciences, Cell Biology, Molecular Biology +16

DAP‐kinase is a Ca2+/calmodulin‐dependent, cytoskeletal‐associated protein kinase, with cell death‐inducing functions that depend on its catalytic activity

Ofer Cohen · The EMBO Journal · 1997 · 414 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

DAP kinase links the control of apoptosis to metastasis

Boaz Inbal, Ofer Cohen, Sylvie Polak‐Charcon et al. · Nature · 1997 · 391 citations

Life Sciences, Cancer Biology, Cell Biology +12