Decision Analysis — Effects of Prophylactic Mastectomy and Oophorectomy on Life Expectancy among Women with<i>BRCA1</i>or<i>BRCA2</i>Mutations

Abstract

On the basis of a range of estimates of the incidence of cancer, prognosis, and efficacy of prophylactic surgery, our model suggests that prophylactic mastectomy provides substantial gains in life expectancy and prophylactic oophorectomy more limited gains for young women with BRCA1 or BRCA2 mutations.